J Reprod Med
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Randomized Controlled Trial Multicenter Study
French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study.
A previous open study demonstrated that French maritime pine bark extract (Pycnogenol) may soothe menstrual pain in dysmenorrhea. We thus investigated the effects of Pycnogenol on menstrual pain in a double-blind study. ⋯ The analgesic-sparing effect of Pycnogenol increases with duration of supplementation and benefits persist even after discontinuation.