Health Qual Life Out
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Health Qual Life Out · Jan 2006
Randomized Controlled Trial Multicenter StudyHydroxyurea and sickle cell anemia: effect on quality of life.
The Multicenter Study of Hydroxyurea (HU) in Sickle Cell Anemia (MSH) previously showed that daily oral HU reduces painful sickle cell (SS) crises by 50% in patients with moderate to severe disease. The morbidity associated with this disease is known to have serious negative impact on the overall quality of life(QOL) of affected individuals. ⋯ Treatment of SS with HU improves some aspects of QOL in adult patients who already suffer from moderate-to-severe SS.
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Health Qual Life Out · Jan 2006
Randomized Controlled Trial Comparative StudyComparison of the SF-6D and the EQ-5D in patients with coronary heart disease.
The SF-6D was derived from the SF-36. A single summary score is obtained allegedly preserving the descriptive richness and sensitivity to change of the SF-36 into utility measurement. We compared the SF-6D and EQ-5D on domain content, scoring distribution, pre-treatment and change scores. ⋯ Although both instruments appear to measure similar constructs, the EQ-5D and SF-6D are quite different. The low agreement and the differences in median values, scoring range and sensitivity to change after intervention show that the EQ-5D and SF-6D yield incomparable scores in patients with coronary heart disease.