Bmc Med Genet
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We used a gene - based replication strategy to test the reproducibility of prior acute lung injury (ALI) candidate gene associations. ⋯ Prior ALI genetic associations are reproducible and replicate in a trauma cohort. Kernel - based SNP-set analysis is a more powerful method to detect ALI association than single SNP analysis, and thus may be more useful for replication testing. Further, gene-based replication can extend candidate gene associations to diverse ethnicities.