Age and ageing
-
Randomized Controlled Trial
Duloxetine for the management of pain in older adults with knee osteoarthritis: randomised placebo-controlled trial.
pain is the leading symptom of osteoarthritis (OA) and is often chronic in nature, leading to significant morbidity and decreased quality of life. Duloxetine, a selective serotonin norepinephrine reuptake inhibitor has been demonstrated to have a centrally acting analgesic effect. ⋯ the findings of the present study provide evidence for the efficacy and tolerability of duloxetine in reducing pain and subsequently improving function in older adults with knee OA.
-
Randomized Controlled Trial
Preventing delirium in an acute hospital using a non-pharmacological intervention.
delirium is a clinical syndrome associated with multiple short and long-term complications and therefore prevention is an essential part of its management. This study was designed to assess the efficacy of multicomponent intervention in delirium prevention. ⋯ the results of this study show that there is a benefit in the non-pharmacological prevention of delirium using family members, when compared with standard management of patients at risk of developing this condition.
-
Randomized Controlled Trial
Community falls prevention for people who call an emergency ambulance after a fall: an economic evaluation alongside a randomised controlled trial.
we estimated the cost-effectiveness of a community falls prevention service compared with usual care from a National Health Service and personal social services perspective over the 12 month trial period. ⋯ the community falls prevention service was estimated to be cost-effective in this high-risk group. Current Controlled Trials ISRCTN67535605. (controlled-trials.com).