Cns Drugs
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Assessing therapeutic efficacy in a progressive disease: a study of donepezil in Alzheimer's disease.
To determine the value of continued donepezil treatment in patients with Alzheimer's disease for whom clinical benefit was initially judged to be uncertain. ⋯ Most patients showed clear clinical benefit during initial donepezil treatment. Among patients for whom clinical benefit was uncertain, improvement in cognition and behaviour were observed for those who continued donepezil treatment compared with the group switched to placebo. Initial decline or stabilisation does not necessarily indicate a lack of efficacy in Alzheimer's disease, and the decision to discontinue treatment should be based on an evaluation of all domains (cognition, behaviour and ADL) and performed at several timepoints.
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Randomized Controlled Trial Multicenter Study
Efficacy and tolerability of zolmitriptan oral tablet in the acute treatment of menstrual migraine.
To determine the efficacy and tolerability of zolmitriptan 2.5 mg oral tablet as an acute treatment for menstrual migraine attacks. ⋯ Oral zolmitriptan is effective and well tolerated for the acute treatment of menstrual migraine attacks. The results are similar to those seen with zolmitriptan in studies of the general migraine population.