Curr Opin Invest Dr
-
Curr Opin Invest Dr · Sep 2004
ReviewThe serotonin receptor and transporter as potential therapeutic targets for pulmonary hypertension.
Pulmonary hypertension (PHT) results from compromised pulmonary vasoconstriction and vascular remodeling. Serotonin (5-hydroxytryptamine/5-HT) is one of the important vasomotor agents, and its importance in the pathogenesis of PHT is currently being investigated. ⋯ Both are therefore potential therapeutic targets for the treatment of the disorder. This review describes current awareness of the roles of 5-HT, the 5-HT receptor and the 5-HTT in PHT.