Int J Clin Pharm Th
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Int J Clin Pharm Th · Sep 2008
Randomized Controlled TrialPopulation pharmacokinetics study of remifentanil in Chinese adult patients determined by an LC-MS/MS method.
The aim of this study was to construct the population pharmacokinetic model in Chinese adult patients and to characterize the factors that affect the parameters of remifentanil pharmacokinetics. ⋯ The LC-MS/MS method for the quantification of remifentanil in human whole blood was rapid, selective and highly sensitive. The population model was acceptable and would be helpful for clinicians to assess the remifentanil pharmacokinetic parameters based on patient's specific demographic characteristics.