Int J Clin Pharm Th
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Int J Clin Pharm Th · Nov 2016
Evaluation of a novel autoinjector for subcutaneous self-administration of belimumab in systemic lupus erythematosus .
To study self-administration and pharmacokinetics (PK) of subcutaneous (SC) belimumab in patients with systemic lupus erythematosus (SLE). ⋯ Patients with SLE successfully self-administered belimumab SC using a novel autoinjector; the PK profile was stable following a switch from IV with acceptable AE and pain levels. The recommended dosing interval between IV to SC dosing is 1 - 4 weeks. .
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Int J Clin Pharm Th · Mar 2016
Randomized Controlled TrialIntrathecal dexmedetomidine as adjuvant to ropivacaine in hysteroscopic surgery: a prospective, randomized control study.
To compare the effects and side effects of intrathecal ropivacaine supplemented with dexmedetomidine and fentanyl in hysteroscopic surgery under spinal anesthesia. ⋯ Intrathecal dexmedetomidine (5 μg) produced prolonged motor and sensory blockade and less pruritus compared with fentanyl (15 μg) in hysteroscopic surgery.
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Int J Clin Pharm Th · Dec 2015
Pharmacokinetic and pharmacodynamic study of dexmedetomidine in elderly patients during spinal anesthesia.
The application of dexmedetomidine in patient sedation is generally accepted, though its clinical application is limited because of the lack of information detailing the specific properties among diverse populations of patients. The aim of this study was to compare the pharmacokinetic and pharmacodynamic characteristics of dexmedetomidine between elderly and young patients during spinal anesthesia. ⋯ The clearance of dexmedetomidine in elderly patients showed a declining trend compared to young patients. Interventions in the elderly group were more frequent than in the young group, and the elderly group showed significant adverse effects. It is suggested that elderly patients who use dexmedetomidine may benefit from a different dose. However, further research with a larger population size is required to confirm these findings.