Arch Gen Psychiat
-
Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Effects of antidepressant medication on morbidity and mortality in depressed patients after myocardial infarction.
Depression after myocardial infarction (MI) is associated with higher morbidity and mortality. Although antidepressants are effective in reducing depression, their use in patients with cardiovascular disease remains controversial. ⋯ Use of selective serotonin reuptake inhibitors in depressed patients who experience an acute MI might reduce subsequent cardiovascular morbidity and mortality. A controlled trial is needed to examine this important issue.