J Am Board Fam Med
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Randomized Controlled Trial
Azithromycin for bronchial asthma in adults: an effectiveness trial.
Macrolides have antimicrobial and anti-inflammatory properties that may be useful in the treatment of chronic asthma. ⋯ Adults with asthma who were randomized to azithromycin did not show statistically significant improvement in asthma outcomes, although the study was underpowered to detect clinical improvement in 15% (number needed to treat = 7). Adults with severe persistent asthma who elected OL treatment documented clinical improvements in asthma symptoms, AQL, and asthma control that persisted after completion of OL azithromycin (number needed to treat = 2).