Plos One
-
Review Meta Analysis
The size of endotracheal tube and sore throat after surgery: a systematic review and meta-analysis.
Use of smaller-sized ETT results in less post-operative sore throat in female patients.
pearl -
Review Meta Analysis
The global epidemiology and contribution of cannabis use and dependence to the global burden of disease: results from the GBD 2010 study.
Estimate the prevalence of cannabis dependence and its contribution to the global burden of disease. ⋯ Cannabis dependence is a disorder primarily experienced by young adults, especially in higher income countries. It has not been shown to increase mortality as opioid and other forms of illicit drug dependence do. Our estimates suggest that cannabis use as a risk factor for schizophrenia is not a major contributor to population-level disease burden.
-
Review Meta Analysis
Risk of bacterial meningitis in young children with a first seizure in the context of fever: a systematic review and meta-analysis.
Of major concern in any febrile child presenting with a seizure is the possibility of bacterial meningitis (BM). We did a systematic review to estimate the risk of BM among various subgroups of young children with a first seizure in the context of fever, and to assess the utility of routine lumbar puncture (LP) in children with an apparent first FS. ⋯ The values provided from this study provide a basis for an evidence-based approach to the management of different subgroups of children presenting to emergency care with a first seizure in the context of fever.
-
Review Meta Analysis
Are treatments more effective than placebos? A systematic review and meta-analysis.
Placebos are widely used in clinical practice in spite of ethical restrictions. Whether such use is justified depends in part on the relative benefit of placebos compared to 'active' treatments. A direct test for differences between placebo and 'active' treatment effects has not been conducted. ⋯ Placebos and treatments often have similar effect sizes. Placebos with comparatively powerful effects can benefit patients either alone or as part of a therapeutic regime, and trials involving such placebos must be adequately blinded.
-
Review Meta Analysis
Are treatments more effective than placebos? A systematic review and meta-analysis.
Placebos are widely used in clinical practice in spite of ethical restrictions. Whether such use is justified depends in part on the relative benefit of placebos compared to 'active' treatments. A direct test for differences between placebo and 'active' treatment effects has not been conducted. ⋯ Placebos and treatments often have similar effect sizes. Placebos with comparatively powerful effects can benefit patients either alone or as part of a therapeutic regime, and trials involving such placebos must be adequately blinded.