Pediatrics
-
Randomized Controlled Trial Comparative Study
Equimolar nitrous oxide/oxygen versus placebo for procedural pain in children: a randomized trial.
This randomized, single-dose, double-blind, Phase III study was designed to compare the level of procedural pain after use of premixed equimolar mixture of 50% oxygen and nitrous oxide (EMONO) or placebo (premixed 50% nitrogen and oxygen). ⋯ EMONO inhalation was well tolerated and had an estimated analgesic potency of 50%, and it is therefore suitable for minor pediatric procedures.