Neuroendocrinol Lett
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Neuroendocrinol Lett · Jan 2011
Central diabetes insipidus is not a common and prognostically worse type of hypernatremia in neurointensive care.
Hypernatremia is a common sodium dysbalance in neurointensive care which is associated with worse outcome. It can be caused by central diabetes insipidus (cDI) or by other mechanisms, more often from osmotherapy and furosemide. The aim of this study was to determine the incidence of cDI and to analyse outcome as compared with other causes of hypernatremias found in neurointesive care. ⋯ Central diabetes insipidus is not a frequent type of hypernatremia in neurointensive care. Prognosis is connected with serum sodium level, not with type of hypernatremia.
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Neuroendocrinol Lett · Jan 2011
Young advisors to the Ombudsman as co-operators of child psychiatry.
In Slovakia, Legislation regulates the rights of individuals with mental disorders. Observance of these regulations is monitored by a designated Ombudsman or Public Defender of Rights which was created with the adoption of the Constitutional Act No. 90/2001. The Public Defender of Rights pays special attention toward the young generation including mentally handicapped children which since 2002 serves as the basis for collaboration with Child Ombudsmen who also act in prevention of Child Abuse and Neglect Syndrome (CAN). Problematic children receive little attention not only in Slovakia. ⋯ An international network of Child Ombudspersons aimed at preventing development of mental and physical damage has been developed. Functioning in 22 European countries within The European Network of Ombudspersons for Children was implemented on a greater scale in April 2010. The Child Ombudspersons should be included in all public healthcare system.
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Neuroendocrinol Lett · Jan 2011
ReviewDisrupted chronobiology of sleep and cytoprotection in obesity: possible therapeutic value of melatonin.
From a physiological perspective the sleep-wake cycle can be envisioned as a sequence of three physiological states (wakefulness, non-rapid eye movement, NREM, sleep and REM sleep) which are defined by a particular neuroendocrine-immune profile regulating the metabolic balance, body weight and inflammatory responses. Sleep deprivation and circadian disruption in contemporary "24/7 Society" lead to the predominance of pro-orexic and proinflammatory mechanisms that contribute to a pandemic metabolic syndrome (MS) including obesity, diabetes and atherosclerotic disease. Thus, a successful management of MS may require a drug that besides antagonizing the trigger factors of MS could also correct a disturbed sleep-wake rhythm. ⋯ More recently, attention has been focused on the development of potent melatonin analogs with prolonged effects (ramelteon, agomelatine, tasimelteon, TK 301). In clinical trials these analogs were employed in doses considerably higher than those usually employed for melatonin. In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin doses in the range of 50-100 mg/day are needed to assess its therapeutic value in MS.
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Neuroendocrinol Lett · Jan 2011
Case ReportsPeripheral nerve stimulation in intractable neuropathic pain.
Peripheral nerve stimulation (PNS) is a neurostimulation analgesic technique. PNS is utilized to treat peripheral neuropathic pain. It is highly sophisticated and a specialized technique used where other forms of treatment have failed. ⋯ In the second part, a case of intractable neuropathic pain following repeated surgery to the ulnar nerve is reported. Prior to PNS, the patient underwent multiple types of antineuralgic treatment with no significant result. Only after the PNS application, was a significant analgesic effect achieved.
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Neuroendocrinol Lett · Jan 2011
N-terminal pro-B-type natriuretic peptide with fractional excretion and clearance of sodium in relation to cardiovascular events after elective cervical spine surgery.
N-terminal pro-B-type natriuretic peptide (NT-proBNP) is increasingly being used as a biomarker of cardiovascular risk. To date neither its cut-off for postoperative period in noncardiac surgery nor whether the cardiovascular risk has any relation to natriuresis has been assessed. ⋯ The significant postoperative elevation of NT-proBNP had no relationship with the rise in FENa+, CNa+ or fUNa+ and was not connected with any occurrence of cardiovascular events in patients after elective cervical spine surgery.