Jpen Parenter Enter
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Jpen Parenter Enter · Mar 2012
Compounding USP <797>: inspection, regulation, and oversight of sterile compounding pharmacies.
Using USP Chapter <797> Pharmaceutical Compounding-Sterile Preparations (CSP) is now considered the standard for sterile compounding practice and safety in the United States. This is particularly important in compounding the complex formulation of parenteral nutrition.
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Jpen Parenter Enter · Mar 2012
Comparative StudyParenteral nutrition prescribing processes using computerized prescriber order entry: opportunities to improve safety.
The prescribing and processing of parenteral nutrition (PN) orders for pediatric patients may involve multiple steps, be time-consuming, and have opportunity for error if safety measures are not in place. The process can vary from institution to institution. The authors conducted a comparison of their system for the prescribing and processing of PN orders with the American Society for Parenteral and Enteral Nutrition's (A. ⋯ There was a 5% overall pharmacist intervention rate on PNs, similar to the 6%-8% rate seen with other medications. Approximately 6% of these PN interventions had an outcome associated with preventing an adverse drug reaction, toxicity, or medication error. Implementation of additional safety measures and standardization may have a positive impact on the complicated process of prescribing and processing PN orders at the authors' institution.
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Parenteral nutrition (PN) is a complex prescription consisting of many components such as dextrose, amino acids, electrolytes, vitamins, trace elements, and/or intravenous fat emulsions. The ordering process is inconsistent and has led to PN errors. PN prescriptions require knowledge, education for prescribers, and standardized processes.
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Safe practices for sterile compounding are essential to preventing errors, particularly with parenteral nutrition (PN). This article reports several areas of errors in PN processes and provides recommendations for error prevention.
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Jpen Parenter Enter · Mar 2012
Enteral feeding induces early intestinal adaptation in a parenterally fed neonatal piglet model of short bowel syndrome.
Successful small intestinal (SI) adaptation following surgical resection is essential for optimizing newborn growth and development, but the potential for adaptation is unknown. The authors developed an SI resection model in neonatal piglets supported by intravenous and enteral nutrition. ⋯ This new model demonstrated profound SI adaptation, initiated early postsurgery by polyamine synthesis and crypt cell proliferation and only in response to enteral feeding. These changes translated to greater gut mass and length within days, likely improving functional capacity long term.