Pediatr Crit Care Me
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Pediatr Crit Care Me · Sep 2012
Prophylactic zinc supplementation reduces bacterial load and improves survival in a murine model of sepsis.
We previously demonstrated that altered zinc homeostasis is an important feature of pediatric sepsis, thus raising the possibility of zinc supplementation as a therapeutic strategy in sepsis. Herein, we tested the hypothesis that prophylactic zinc supplementation would be beneficial in a murine model of peritoneal sepsis. ⋯ Prophylactic zinc supplementation reduces bacterial load and is beneficial in a murine model of peritoneal sepsis.