Pediatr Crit Care Me
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Pediatr Crit Care Me · Mar 2013
Multicenter Study Comparative StudyClinical outcomes of children receiving intensive cardiopulmonary support during hematopoietic stem cell transplant.
We investigated the short-term and 1-year clinical outcomes of 129 children who received intensive cardiopulmonary support during hematopoietic stem cell transplant. Intensive cardiopulmonary support was defined as receiving at least one of the following interventions: continuous positive pressure ventilation, dopamine infusion greater than or equal to 10 mcg/kg/minute, or the use of any other vasoactive infusion. Duration of intensive cardiopulmonary support, survival to hospital discharge, and predictors of these outcome variables were compared with 387 hematopoietic stem cell transplant patients who did not receive intensive support during the same period. We also report the 1-year survival; presence of chronic graft-versus-host disease; and renal, cardiac, and pulmonary function for all patients. ⋯ Intensive cardiopulmonary support plays an important and potentially life-saving role in the care of pediatric stem cell transplant patients. Survivors of intensive support do not have compromised 1-year survival or organ function compared with children who did not receive intensive support.
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Pediatr Crit Care Me · Mar 2013
Multicenter StudyA multicenter outcomes analysis of children with severe viral respiratory infection due to human metapneumovirus.
To investigate the impact of human metapneumovirus on morbidity and mortality outcomes in children with severe viral respiratory infection. ⋯ Analysis of our results suggests that there is substantial morbidity and mortality associated with severe viral respiratory infection due to human metapneumovirus in children. Female gender, hospital acquisition of human metapneumovirus infection, and presence of chronic medical conditions each independently increases mortality. The burden of illness from human metapneumovirus on the ICU in terms of resource utilization may be considerable.