Pediatr Crit Care Me
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Pediatr Crit Care Me · Jul 2013
Clinical TrialSildenafil exposure and hemodynamic effect after stage II single-ventricle surgery.
To determine sildenafil exposure and hemodynamic effect in children after stage II single-ventricle surgery. ⋯ Sildenafil demonstrated nonlinear exposure with high interindividual variability but was well tolerated and effectively lowered pulmonary vascular resistance index in all subjects. Sildenafil did not acutely improve myocardial performance or increase cardiac index.
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Pediatr Crit Care Me · Jul 2013
Point prevalence survey of antimicrobial utilization in the cardiac and pediatric critical care unit.
To determine the rate of documented infections and prevalence of antimicrobial use among pediatric patients admitted to the PICU. To assess the appropriateness of antimicrobial prescribing according to clinical and microbiological findings, Infectious Disease Consult recommendations, and formulary guidelines. ⋯ There was a high prevalence of antimicrobial use in CCCU-PICU patients. Because a significant proportion of antimicrobial use was deemed inappropriate, interventions are required to optimize antimicrobial use in critically ill children.