Pediatr Crit Care Me
-
Pediatr Crit Care Me · Jun 2015
Glucocorticoid Receptor Expression in Peripheral WBCs of Critically Ill Children.
To characterize glucocorticoid receptor expression in peripheral WBCs of critically ill children using flow cytometry. ⋯ Our study suggests that patients with shock and increased severity of illness have lower glucocorticoid receptor expression in CD4 and CD8 lymphocytes. Glucocorticoid receptor expression does not correlate well with cortisol levels. Future studies could focus on studying glucocorticoid receptor expression variability and isoform distribution in the pediatric critically ill population as well as on different strategies to optimize glucocorticoid response.
-
Pediatr Crit Care Me · Jun 2015
Diagnostic and Prognostic Value of Serum Cystatin C in Critically Ill Children With Acute Kidney Injury.
We aimed to evaluate the value of serum cystatin C for detection of acute kidney injury and pediatric Risk, Injury, Failure, Loss, End-Stage Renal Disease categories in critically ill children and to investigate whether serum cystatin C was associated with outcome. ⋯ Cystatin C is an early and accurate biomarker for acute kidney injury and pediatric Risk, Injury, Failure, Loss, End-Stage Renal Disease categories, and it is associated with adverse clinical outcomes in a heterogeneous population of critically ill children.
-
Pediatr Crit Care Me · Jun 2015
Multicenter StudyEvolution of Noninvasive Mechanical Ventilation Use: A Cohort Study Among Italian PICUs.
To assess how clinical practice of noninvasive ventilation has evolved in the Italian PICUs. ⋯ Noninvasive ventilation is increasingly and successfully used as first respiratory approach in several, but not all, Italian PICUs. The current study shows that noninvasive ventilation represents a feasible and safe technique of ventilatory assistance for the treatment of mild acute respiratory failure. Noninvasive ventilation was used as primary mode of ventilation in children with low respiratory tract infection (mainly in bronchiolitis and pneumonia), in acute on chronic respiratory failure or to prevent reintubation.