Pediatr Crit Care Me
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Pediatr Crit Care Me · Jun 2015
Randomized Controlled Trial Multicenter StudySafety and Efficacy of Sodium Nitroprusside During Prolonged Infusion in Pediatric Patients.
Sodium nitroprusside is a direct-acting vasodilator used to lower blood pressure in the operating room and ICU. The efficacy of sodium nitroprusside has been analyzed in few pediatric randomized trials. This study assesses the efficacy and safety of sodium nitroprusside following at least 12 hours of IV infusion in children. ⋯ Sodium nitroprusside is efficacious in maintaining mean arterial blood pressure control in children following a 12-hour infusion. Although a high proportion of patients were found to have elevated cyanide levels, toxicity was not observed.
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Pediatr Crit Care Me · Jun 2015
Multicenter StudyEvolution of Noninvasive Mechanical Ventilation Use: A Cohort Study Among Italian PICUs.
To assess how clinical practice of noninvasive ventilation has evolved in the Italian PICUs. ⋯ Noninvasive ventilation is increasingly and successfully used as first respiratory approach in several, but not all, Italian PICUs. The current study shows that noninvasive ventilation represents a feasible and safe technique of ventilatory assistance for the treatment of mild acute respiratory failure. Noninvasive ventilation was used as primary mode of ventilation in children with low respiratory tract infection (mainly in bronchiolitis and pneumonia), in acute on chronic respiratory failure or to prevent reintubation.