Pediatr Crit Care Me
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Pediatr Crit Care Me · Jun 2017
Randomized Controlled Trial Multicenter StudyA Randomized Controlled Trial of Corticosteroids in Pediatric Septic Shock: A Pilot Feasibility Study.
To determine the feasibility of conducting a randomized controlled trial of corticosteroids in pediatric septic shock. ⋯ This study suggests that a large randomized controlled trial on early use of corticosteroids in pediatric septic shock is potentially feasible. However, the frequent use of empiric corticosteroids in otherwise eligible patients remains a significant challenge. Knowledge translation activities, targeted recruitment, and alternative study designs are possible strategies to mitigate this challenge.