Pediatr Crit Care Me
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Pediatr Crit Care Me · Sep 2023
Adaptive Clinical Trials in Pediatric Critical Care: A Systematic Review.
This systematic review investigates the use of adaptive designs in randomized controlled trials (RCTs) in pediatric critical care. ⋯ Little evidence of the use of adaptive designs was found, with only 3% of PICU RCTs incorporating an adaptive design and only two types of adaptations used. Identifying the barriers to adoption of more complex adaptive trial designs is needed.