P R Health Sci J
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Randomized Controlled Trial
Timing of ondansetron administration to prevent postoperative nausea and vomiting.
The original guidelines for using ondansetron recommending its administration prior to induction of anesthesia have been questioned. ⋯ This clinical study indicates that when performing prolonged surgical procedures, late administration of ondansetron (within 30 minutes prior to completing the surgery) is significantly more effective in the prevention of late PONV than when administered prior to the induction of anesthesia.