Psychosomatics
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Randomized Controlled Trial
Administration of olanzapine to prevent postoperative delirium in elderly joint-replacement patients: a randomized, controlled trial.
Delirium is a serious postoperative condition for which few pharmacologic prevention trials have been conducted. ⋯ Administration of 10 mg of oral olanzapine perioperatively, versus placebo, was associated with a significantly lower incidence of delirium. These findings suggest that olanzapine prophylaxis of postoperative delirium may be an effective strategy.