British medical bulletin
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British medical bulletin · Jan 2013
ReviewHealth of China's rural-urban migrants and their families: a review of literature from 2000 to 2012.
Socioeconomic transformation in China at the beginning of the twenty-first century has led to rapid urbanization and accelerated rural-urban migration. As a result, the concerns about public health problems triggered by increasing internal population mobility have been more widely studied in recent years. ⋯ Social, economic, emotional, environmental and behavioural risk factors that impact on health of migrants and their families call for more attention from health policy-makers and researchers in contemporary China.
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British medical bulletin · Jan 2013
ReviewThe angiogenic properties of mesenchymal stem/stromal cells and their therapeutic potential.
Blood vessel formation is fundamental to development, while its dysregulation can contribute to serious disease. Expectations are that hundreds of millions of individuals will benefit from therapeutic developments in vascular biology. MSCs are central to the three main vascular repair mechanisms. ⋯ Characterization of MSCs' in vivo origins and biological properties in relation to their localization within tissue niches, reprogramming strategies and newer imaging/bioengineering approaches.
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British medical bulletin · Jan 2013
ReviewUnderstanding the genetic aetiology in patients with XY DSD.
Disorders of sex development (DSD) consist of a wide range of disorders and are commoner in those with an XY karyotype. In over half of these cases who have a 46,XY karyotype and who are raised as boys, the underlying aetiology remains unclear. ⋯ There is a need to understand and improve the clinical utility of genetic analysis in the clinical setting of the patient with a suspected DSD. This will be even more important when parallel gene sequencing identifies variations in multiple genes.
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British medical bulletin · Jan 2013
ReviewUpdate on the long-term complications of renal transplantation.
Powerful immunosuppressive regimens have reduced rejection risk, leading to an expanding cohort of long-term kidney transplant recipients who are likely to encounter practitioners in other specialties. ⋯ Markers to guide individualized optimal immunosuppression and predict the development of complications would allow for targeted early intervention.
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The public assumes that if euthanasia and assisted suicide were to be legalized they would be carried out by physicians. ⋯ The impact of characterizing euthanasia as 'medical treatment' on physicians' professional identity and on the institutions of medicine and law should be examined in jurisdictions where assisted suicide and euthanasia have been de-criminalized.