Crit Care Resusc
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Review Meta Analysis
The effect of antipyretic medications on mortality in critically ill patients with infection: a systematic review and meta-analysis.
Antipyretic medications are widely used in critically ill patients with infection despite evidence supporting a protective, adaptive role of fever. ⋯ The studies included in this review were insufficient to allow a robust estimate of the effect of pharmacological antipyresis on mortality in critically ill patients with suspected infection. Further RCTs are required to resolve this important area of clinical uncertainty.