Crit Care Resusc
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Randomized Controlled Trial Multicenter Study Comparative Study
Statistical analysis plan for the Crystalloid Versus Hydroxyethyl Starch Trial (CHEST).
The Crystalloid Versus Hydroxyethyl Starch Trial (CHEST) is a 7000-patient, multicentre, randomised controlled trial comparing the effects of 6% hydroxyethyl starch (130/0.4) to normal saline for fluid resuscitation in intensive care patients. The trial design is based on the Saline Versus Albumin Fluid Evaluation (SAFE) study and will be the largest fluid resuscitation trial conducted to date. ⋯ We have developed a predetermined SAP for CHEST. This plan accords with high-quality standards of internal validity to minimise analysis bias.
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Multicenter Study
The association between early arterial oxygenation and mortality in ventilated patients with acute ischaemic stroke.
There are conflicting data that suggest that hyperoxia may be associated with either worse or better outcomes in patients suffering a stroke. ⋯ We found no association between worst arterial oxygen tension in the first 24 hours in ICU and outcome in ventilated patients with ischaemic stroke.