Crit Care Resusc
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Randomized Controlled Trial Multicenter Study Comparative Study
Safety evaluation of a trial of lipocalin-directed sodium bicarbonate infusion for renal protection in at-risk critically ill patients.
Urine alkalinisation with sodium bicarbonate decreases renal oxidative stress and might attenuate sepsisassociated acute kidney injury (s-AKI). The safety and feasibility of urine alkalinisation in patients at risk of s-AKI has never been tested. ⋯ Administration of sodium bicarbonate and sodium chloride solutions to patients at risk of s-AKI was associated with frequent major electrolyte abnormalities and early protocol cessation. The tested protocol does not appear safe or feasible.
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Randomized Controlled Trial Multicenter Study Comparative Study
The ADRENAL study protocol: adjunctive corticosteroid treatment in critically ill patients with septic shock.
There is considerable global uncertainty on the role of low-dose corticosteroids in septic shock, which translates into variations in prescribing practices. ⋯ The run-in phase has been completed and the main trial commenced in February 2013. The trial should generate results that will inform and influence prescribing of corticosteroids in septic shock.
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Randomized Controlled Trial Multicenter Study Comparative Study
A randomised controlled trial of induced hypermagnesaemia following aneurysmal subarachnoid haemorrhage.
The effect of serum magnesium concentration on the incidence of cerebral arterial vasospasm following aneurysmal subarachnoid haemorrhage (SAH) is unclear. ⋯ Patients assigned a higher serum magnesium concentration had a reduced incidence of vasospasm as seen by angiography, but the difference was not statistically significant. Clinically significant outcomes were not different between groups. A firm recommendation for induced hypermagnesaemia cannot be made from this study.
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Multicenter Study Comparative Study
Severe sepsis and septic shock in patients with pre-existing non-cardiac pulmonary hypertension: contemporary management and outcomes.
To review treatment and outcomes of septic shock in patients with pulmonary hypertension (PH) managed at a tertiary care institution. ⋯ The severity of PH, new-onset AF, and longer vasopressor support were associated with poor outcomes in patients with PH who developed severe sepsis and septic shock.
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Multicenter Study Comparative Study
Inappropriate continuation of stress ulcer prophylaxis beyond the intensive care setting.
To determine how frequently stress ulcer prophylaxis (SUP) medications prescribed in the intensive care unit are inappropriately continued on the ward and on hospital discharge. ⋯ SUP medications commenced in ICU are frequently continued unnecessarily, both in the wards and hospital discharge.