Amyotroph Lateral Sc
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Amyotroph Lateral Sc
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Amyotroph Lateral Sc · Dec 2006
Review Meta AnalysisEffect of non-invasive ventilation on survival, quality of life, respiratory function and cognition: a review of the literature.
Symptoms of nocturnal hypoventilation may negatively influence the quality of life (QoL) of ALS patients long before respiratory failure ensues. Non-invasive mechanical ventilation (NIV) is considered a treatment option for nocturnal hypoventilation. The primary objective of NIV is improving quality of life (QoL). ⋯ In conclusion, studies on the use of NIV in ALS differ in study design and endpoint definitions. All studies suggest a beneficial effect on QoL and other outcome measures (Evidence level Class II-III). Well-designed randomized controlled trials comparing the effect on QoL and survival have not been performed.