Arch Neurol Chicago
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Arch Neurol Chicago · Sep 1997
Randomized Controlled Trial Comparative Study Clinical TrialA comparison of divalproex with propranolol and placebo for the prophylaxis of migraine without aura.
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Arch Neurol Chicago · Jun 1997
Randomized Controlled Trial Clinical TrialBuspirone, a 5-hydroxytryptamine1A agonist, is active in cerebellar ataxia. Results of a double-blind drug placebo study in patients with cerebellar cortical atrophy.
To establish the antiataxic effect of buspirone hydrochloride, a serotonergic 5-hydroxytryptamine1A (5-HT1A) agonist, in a homogenous group of patients characterized by the same well-defined single condition, cerebellar cortical atrophy. ⋯ Buspirone is active in cerebellar ataxia of patients with cerebellar atrophy. These results confirm the data suggested by open-label studies with buspirone. However, the effect is partial and not clinically major. These pharmacological results might be due to serotonergic mechanisms and confirm a possible link between cerebellar ataxia and the metabolism of serotonin.
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Arch Neurol Chicago · May 1997
Randomized Controlled Trial Clinical TrialNeuromuscular blocking drugs do not alter the pupillary light reflex of anesthetized humans.
To test the hypothesis that systemically administered neuromuscular blocking drugs acutely alter resting pupil size or the direct reflex response to light in anesthetized humans. ⋯ We conclude that systemically administered neuromuscular blocking drugs (vecuronium and pancuronium) do not acutely affect the pupillary light reflex in healthy, anesthetized patients.
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Arch Neurol Chicago · Aug 1996
Randomized Controlled Trial Clinical TrialSafety and tolerance of multiple doses of intramuscular fosphenytoin substituted for oral phenytoin in epilepsy or neurosurgery.
Safety, tolerability, and pharmacokinetics of fosphenytoin sodium, a water-soluble phenytoin prodrug, were investigated after a temporary substitution of intramuscular fosphenytoin for oral phenytoin sodium in 240 epileptic or neurosurgical patients taking oral phenytoin sodium (100-500 mg/d). ⋯ Dosing adjustments are not required when intramuscular fosphenytoin is temporarily substituted or oral phenytoin therapy is resumed. Intramuscular fosphenytoin is a safe and well-tolerated alternative to oral phenytoin when oral administration is not feasible.
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Arch Neurol Chicago · May 1996
Randomized Controlled Trial Comparative Study Clinical TrialCiticoline improves verbal memory in aging.
To test the verbal memory of older volunteers given citicoline. ⋯ Citicoline therapy improved verbal memory functioning in older individuals with relatively inefficient memories. Citicoline may prove effective in treating age-related cognitive decline that may be the precursor of dementia.