Neurol Neurochir Pol
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Neurol Neurochir Pol · Jan 2015
Meta AnalysisAssociation of migraine headaches with anatomical variations of the Circle of Willis: Evidence from a meta-analysis.
Several studies have attempted to investigate whether variations in the Circle of Willis (COW) are more common in migraine patients and whether the subsequent changes in perfusion may contribute to the pathomechanism of migraine. However, studies are not in agreement as to whether or not there is an increased prevalence of COW variations in migraineurs. ⋯ Migraine is associated with anatomical variations in both the anterior and posterior portions of the COW. However, larger prospective trials are needed to determine the true prevalence of variations and their pathological significance.