Clin Lab
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The use of colloidal silica contained in different cryopellet formulations is examined as a contact activator of blood in an intrinsic coagulation test. In particular the necessary amount of silica per cryopellet was determined, as well as the interfering effects of cryopellet components on coagulation. ⋯ A silica-containing cryopellet can be prepared and works as well as ellagic acid as an activator in intrinsic rotational thromboelastometry. A cryopellet avoids dilution of the whole blood sample and hence also of coagulation-relevant blood components that can alter the coagulation result.