J Rheumatol
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Randomized Controlled Trial Clinical Trial
Efficacy and safety of tramadol HCl in breakthrough musculoskeletal pain attributed to osteoarthritis.
To evaluate the efficacy of tramadol as adjunctive therapy in patients with musculoskeletal pain attributed to osteoarthritis (OA) who experienced breakthrough pain while taking a nonsteroidal antiinflammatory drug (NSAID). ⋯ Tramadol may have a role as adjunctive treatment for breakthrough pain in patients receiving NSAID therapy for musculoskeletal pain attributed to OA.