J Rheumatol
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
A comparison of once-daily tramadol with normal release tramadol in the treatment of pain in osteoarthritis.
To compare the efficacy and tolerability of once daily (OD) tramadol tablets with normal release tramadol capsules (50 mg) taken 3 or 4 times daily in a multicenter, double blind, double dummy parallel study. ⋯ Tramadol OD was at least as effective and well tolerated as normal release tramadol in the management of OA pain. However, OD tramadol offers the advantage of a reduced dosing regimen, which is especially valuable in the elderly population.