J Rheumatol
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Efficacy of rofecoxib, celecoxib, and acetaminophen in patients with osteoarthritis of the knee. A combined analysis of the VACT studies.
To compare efficacy among 1578 patients with osteoarthritis randomized to take acetaminophen 4000 mg (n=269), celecoxib 200 mg (n=523), rofecoxib 12.5 mg (n=259), or rofecoxib 25 mg (n=527) in a double blind trial [Vioxx, Acetaminophen, Celecoxib Trial (VACT2)]. Results were also pooled with the similarly designed VACT1 trial. ⋯ Rofecoxib and celecoxib provided superior efficacy to acetaminophen. There was a more rapid and greater response with rofecoxib 25 mg than celecoxib 200 mg. Rofecoxib 12.5 mg demonstrated greater efficacy than celecoxib 200 mg over the first 6 days, and was similar over 6 weeks. All study medications were generally well tolerated.
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Randomized Controlled Trial Clinical Trial
A randomized, double-blind, placebo controlled triphosphate in study of oral adenosine subacute low back pain.
To assess the efficacy and safety of oral adenosine triphosphate (ATP) in subacute low back pain. ⋯ Oral ATP might have an early acting effect in subacute low back pain.