J Rheumatol
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Randomized Controlled Trial
Intraarticular botulinum toxin A for refractory painful total knee arthroplasty: a randomized controlled trial.
To assess short-term efficacy of single intraarticular botulinum toxin (IA-BoNT/A) injection in patients with chronically painful total knee arthroplasty (TKA) in a randomized, placebo-controlled, triple-blind study. ⋯ In this single-center randomized trial, single IA-BoNT/A injection provided clinically meaningful short-term improvements in pain, global assessment, and function in patients with chronic painful TKA. A multicenter trial is needed to confirm these findings.
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Randomized Controlled Trial
Disease activity, physical function, and radiographic progression after longterm therapy with adalimumab plus methotrexate: 5-year results of PREMIER.
To evaluate the efficacy and safety of initial combination treatment with adalimumab (ADA) and methotrexate (MTX) versus monotherapy with ADA or MTX during an open-label extension of PREMIER. ⋯ Initial combination treatment with ADA plus MTX, followed by open-label ADA, led to better longterm clinical, functional, and radiographic outcomes than either initial ADA or MTX monotherapy during 5 years of treatment.
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Randomized Controlled Trial
Effect of a symptom diary on symptom frequency and intensity in healthy subjects.
Symptom and pain diaries are often recommended to or used by patients with chronic pain disorders. Our objective was to examine the effect on recall of symptoms after 14 days of daily symptom diary use in healthy subjects. ⋯ The use of a symptom diary for 2 weeks, even in generally healthy subjects, results in increased recall of daily symptoms and increased perception of symptom severity.