Bmc Gastroenterol
-
Randomized Controlled Trial
A candidate probiotic with unfavourable effects in subjects with irritable bowel syndrome: a randomised controlled trial.
Some probiotics have shown efficacy for patients with irritable bowel syndrome (IBS). Lactobacillus (L.) plantarum MF1298 was found to have the best in vitro probiotic properties of 22 strains of lactobacilli. The aim of this study was to investigate the symptomatic effect of L. plantarum MF1298 in subjects with IBS. Primary outcome was treatment preference and secondary outcomes were number of weeks with satisfactory relief of symptoms and IBS sum score. ⋯ This trial shows for the first time an unfavourable effect on symptoms in subjects with IBS after intake of a potential probiotic.