Laboratory investigation; a journal of technical methods and pathology

The most recent articles from: Lab. Invest. November 1978

Lab. Invest. · Nov 1978

Antiserum-mediated demyelination in vivo: a sequential study using intraneural injection of experimental allergic neuritis serum.

Primary segmental demyelination accompanied by mononuclear phagocytes was induced by injection of antiserum into rat peripheral nerve, and the morphologic sequence of events was studied. Antisera were obtained from rabbits with experimental allergic neuritis (EAN) produced by the inoculation of emulsified bovine peripheral nerves in complete Freund's adjuvant. Sera were injected directly into rat sciatic nerve to circumvent the blood-nerve barrier. ⋯ Silberberg, and M. J. Brown: Nature 272: 639, 1978).

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