World J Gastroentero
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World J Gastroentero
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World J Gastroentero · Mar 2005
Randomized Controlled Trial Multicenter Study Clinical TrialA blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults.
Racecadotril is a specific enkephalinase inhibitor that exhibits intestinal antisecretory activity without affecting intestinal transit. Loperamide is an effective anti-diarrheal agent, but it usually induces constipation. This study is to compare the efficacy, safety, and tolerability of racecadotril versus loperamide in the outpatient treatment of acute diarrhea in adults. ⋯ Racecadotril and loperamide are rapid, equally effective treatments for acute diarrhea in adults, but loperamide treatment is associated with a higher incidence of treatment-related constipation.