Mikrobiyol Bul
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Drug resistance in tuberculosis is a growing global problem. The emergence of multi-drug resistant tuberculosis cases, particularly in the 1990s, has become an important health problem and threatens tuberculosis control worldwide. Resistance to isoniazid and rifampicin, two of the most potent anti-tuberculosis drugs currently available, in multi-drug resistant tuberculosis cases is clinically quite important. ⋯ Recently, a new form of tuberculosis, resistant to all first-and second-line anti-tuberculosis drugs seen in just a few number of cases, has been defined as extremely drug resistant tuberculosis and this is the end point in resistance problem in tuberculosis. In the view of this situation the stages of tuberculosis in terms of developing resistance are as follows: drugsensitive tuberculosis, mono-drug resistant tuberculosis, poly-drug resistant tuberculosis, multi-drug resistant tuberculosis, extensively drug resistant tuberculosis, and extensively drug resistant tuberculosis. In this review, the recent information about drug resistant tuberculosis forms, particularly extremely drug resistant tuberculosis that has been popular since 2005, has been discussed.