Resp Res
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Randomized Controlled Trial Comparative Study
Inhaled furosemide for relief of air hunger versus sense of breathing effort: a randomized controlled trial.
Inhaled furosemide offers a potentially novel treatment for dyspnoea, which may reflect modulation of pulmonary stretch receptor feedback to the brain. Specificity of relief is unclear because different neural pathways may account for different components of clinical dyspnoea. Our objective was to evaluate if inhaled furosemide relieves the air hunger component (uncomfortable urge to breathe) but not the sense of breathing work/effort of dyspnoea. ⋯ Oxford Brookes University Central Research Fund.