J Musculoskel Neuron
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J Musculoskel Neuron · Jun 2017
Impaired fracture healing with high non-union rates remains irreversible after traumatic brain injury in leptin-deficient mice.
Patients with traumatic brain injury (TBI) and long-bone fractures can show increased callus formation. This effect has already been reproduced in wild-type (wt) mice. However, the mechanisms remain poorly understood. ⋯ This study shows that bony bridging is impaired in the present leptin-deficient trauma model. Furthermore, the phenomenon of increased callus formation after TBI could not be reproduced in ob/ob mice, as in wt mice. Our findings suggest that the increased callus formation after TBI may be dependent on leptin signaling.