The Medical journal of Australia
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Randomized Controlled Trial Comparative Study Clinical Trial Controlled Clinical Trial
A comparative study of indomethacin and ibuprofen.
In a double blind trial with 20 patients ibuprofen 1600 mg daily and indomethacin 100 mg daily were shown to be of comparable efficacy in the short-term treatment of rheumatoid arthritis. Reported side effects were similar, but a slightly greater incidence of gastric irritation was noted with indomethacin necessitating withdrawal of one patient from the trial. ⋯ Peak concentrations of both drugs occurred within two hours. Five of the seven patients considered to have comparable serum concentrations of both drugs demonstrated a preference for indomethacin.
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Randomized Controlled Trial Comparative Study Clinical Trial
Treatment of duodenal ulcer with carbenoxolone sodium: a double-masked endoscopic trial.
In a double-masked trial, 43 patients with an endoscopically confirmed, symptomatic duodenal ulcer were allocated at random to treatment with either carbenoxolone sodium or placebo, both provided in identical "positioned-release" capsules. The 40 patients who satisfactorily completed the trial were evenly distributed between the two treatment groups. The groups were well matched with regard to clinical features and initial ulcer size. ⋯ Side effects of carbenoxolone therapy were observed, but they did not necessitate withdrawal of the drug and were readily controlled in every instance. These results confirm the therapeutic efficacy of carbenoxolone sodium in duodenal ulcer. In addition, a relationship between serum carbenoxolone levels and the occurrence of ulcer healing was observed.
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Randomized Controlled Trial Comparative Study Clinical Trial
Efficacy of cimetidine and tri-potassium di-citrato bismuthate (De-Nol) in chronic gastric ulceration: a comparative study.
Sixty patients with benign chronic gastric ulcer were treated in a controlled clinical trial to assess the relative efficacy of cimetidine and tri-potassium di-citrato bismuthate (De-Nol). Patients were assigned at random either to cimetidine or to De-Nol treatment after initial endoscopic diagnosis. Healing was assessed endoscopically after six weeks by an endoscopist who had no knowledge of the patients' treatment. ⋯ Those patients who regularly ingested more than four analgesic preparations a day healed less frequently, but this effect was not statistically significant. There was no significant difference between cimetidine and De-Nol in the initial healing of chronic gastric ulceration. The choice of therapy for chronic gastric ulceration will depend on cost, patient acceptance, and data from studies of more complex therapeutic regimens.