Arch Dermatol
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Randomized Controlled Trial Multicenter Study
Topical tretinoin therapy and all-cause mortality.
To evaluate the relation of topical tretinoin, a commonly used retinoid cream, with all-cause mortality in the Veterans Affairs Topical Tretinoin Chemoprevention Trial (VATTC). The planned outcome of this trial was risk of keratinocyte carcinoma, and systemic administration of certain retinoid compounds has been shown to reduce risk of this cancer but has also been associated with increased mortality risk among smokers. ⋯ We observed an association of topical tretinoin therapy with death, but we do not infer a causal association that current evidence suggests is unlikely.