Ann Acad Med Singap
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In recent years tremendous progress has been made in our understanding of peripheral, spinal cord and brain mechanisms involved in acute pain and in the neurophysiologic description of nociceptive pathways, receptors and mediators. Great strides have been made in our knowledge of pharmacokinetics and pharmacodynamics of drugs used to treat pain. However, in spite of unprecedented interest in pain and its management, most patients undergoing surgery still receive treatments that have changed little in the past decades. ⋯ Various combinations of the above are also possible. However, it is increasingly recognised that the solution to the problem of inadequate pain relief on surgical wards lies not so much in the development of new drugs and new techniques but in the development of a formal organisation for better use of existing drugs and techniques. A simple, low-cost organisation model for acute pain services (APS) is described.
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Ann Acad Med Singap · Nov 1994
ReviewRecent advances in the understanding and management of postoperative nausea and vomiting.
Postoperative nausea and vomiting (PONV) is a common distressing complication of surgery and anaesthesia. The multifactorial aetiology of PONV gives rise to an incidence that varies widely among different patient groups. ⋯ Current research is concentrated on a new class of drugs, the serotonin (5-HT3) receptor antagonists. This review summarizes the experience with these drugs and other recent advances in PONV.
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The development of new non-depolarizing neuromuscular blocking drugs starting with the introduction of the intermediate-acting agents atracurium and vecuronium has made it possible to avoid the use of succinylcholine for elective cases. Recently 4 new drugs have become available; the short-acting mivacurium, the intermediate-acting rocuronium and the 2 long-acting drugs doxacurium and pipecuronium. The pharmacokinetic and pharmacodynamic profile of these drugs are reviewed in this paper.
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Patients undergoing surgery move through a continuum of medical care to which a primary care physician, an internist, an anaesthesiologist, and a surgeon contribute to ensure the best outcome possible. No aspect of medicine requires greater cooperation than the performance of surgery and the perioperative care of a patient. For the anaesthesiologist, this responsibility should start in a preoperative clinic. ⋯ At a time when medical information is encyclopaedic, it is difficult for even the most conscientious anaesthesiologist or surgeon to keep abreast of medical issues relevant to perioperative patient management. Thus, a proposed preoperative assessment clinic facilitates those most sought-after goals, increased quality and reduced costs. As part of this process, ordering only laboratory tests warranted by a patient's symptoms and medical history is important to avoid risks of unnecessary testing and of follow-up of false-positive results.