Ann Acad Med Singap
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Ann Acad Med Singap · Aug 2008
ReviewBasic science review on circadian rhythm biology and circadian sleep disorders.
The sleep-wake cycle displays a characteristic 24-hour periodicity, providing an opportunity to dissect the endogenous circadian clock through the study of aberrant behaviour. This article surveys the properties of circadian clocks, with emphasis on mammals. ⋯ A review of human circadian rhythm sleep disorders follows, including recent discoveries of their genetic basis. The article concludes with a discussion of future approaches to the study of human circadian biology and sleep-wake behaviour.