Ann Acad Med Singap
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Ann Acad Med Singap · Jul 2024
ReviewDemographic diversity of participants in clinical trials conducted in Singapore.
The under-representativeness of participants in clinical trials limits the generalisability of results. This review evaluates the representative-ness within pharmaceutical randomised controlled trials (RCTs) in Singapore. ⋯ There is room for improvement regarding the recruitment of RCT participants in Singapore, with particular attention to female gender and Indian ethnicity. Demographic data should also be presented in full. RCTs should be designed and reported such that clinicians can ascertain the generalisability to the Singapore population and the potential benefits from the studied interventions in clinical practice.
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Ann Acad Med Singap · Jul 2024
Meta AnalysisAssociation between alcohol flushing syndrome and cancer: A systematic review and meta-analysis.
Alcohol flushing syndrome (AFS) is experienced by up to 46% of East Asians. This study aimed to review the risk of cancers in AFS patients, elucidate an exposure-response relationship, and understand risk associated with alcohol intake and cancer. ⋯ AFS is associated with an increased risk of all cancers, particularly esophageal squamous cell carcinoma and gastric adenocarcinoma.