Arch Intern Med
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Randomized Controlled Trial Multicenter Study Clinical Trial
Treatment with alendronate prevents fractures in women at highest risk: results from the Fracture Intervention Trial.
The efficacy of antiresorptive therapy in preventing fractures in women at highest fracture risk, such as very elderly women or those with severe osteoporosis, is uncertain. ⋯ Alendronate effectively reduces fracture risk in postmenopausal women with vertebral fractures and low BMD, including those women at highest risk because of advanced age or severe osteoporosis. Since the risk reductions observed with alendronate treatment were consistent within fracture risk categories, more fractures were prevented by treating women at highest risk.