Arch Intern Med
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Multicenter Study
Depression, falls, and risk of fracture in older women. Study of Osteoporotic Fractures Research Group.
Previous studies have suggested that depression is associated with falls and with low bone density, but it is not known whether depression leads to an increased risk of fracture. ⋯ Depression is a significant risk factor for fracture in older women. The greater frequency of falls among individuals with depression partially explains this finding. Other mechanisms responsible for the association between depression and fracture remain to be determined.