Arch Intern Med
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Multicenter Study Comparative Study
Depression and medication adherence in outpatients with coronary heart disease: findings from the Heart and Soul Study.
Depression leads to adverse outcomes in patients with coronary heart disease (CHD). Medication nonadherence is a potential mechanism for the increased risk of CHD events associated with depression, but it is not known whether depression is associated with medication nonadherence in outpatients with stable CHD. ⋯ Depression is associated with medication nonadherence in outpatients with CHD. Medication nonadherence may contribute to adverse cardiovascular outcomes in depressed patients.