Arch Intern Med
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Meta Analysis Comparative Study
Mixed comparison of stroke prevention treatments in individuals with nonrheumatic atrial fibrillation.
We aimed to identify different stroke prevention treatments for atrial fibrillation assessed in randomized controlled trials and to compare them within a single evidence synthesis framework. ⋯ A lower rate of ischemic stroke and a higher rate of major bleeding episodes were found to be associated with oral anticoagulants compared with aspirin, and both anticoagulants and aspirin were found to be associated with a reduction in the rate of stroke compared with placebo.